Crème VG Derm uses macadamia, jojoba, and yeast extract to deeply hydrate, calm irritation, and repair the skin barrier. Best for dry, sensitive, or post-treatment skin.
If your skin feels tight, flaky, or easily irritated, Crème VG Derm might be your new skin savior. Packed with barrier-repairing oils, soothing botanicals, and skin-identical hydrators, this cream is ideal for dry, sensitive, and post-procedure skin types.
KarinaNYC uses Crème VG Derm in real client protocols where healing is critical.
In this guide, we’ll break down the key ingredients, their benefits, what not to pair it with, and how to build a high-performance routine around it. Let’s dive in.
Not Just Dry Skin: What Your Face Is Really Telling You

When a client comes in with tight, flaky, or reactive skin, nine times out of ten, the issue is barrier damage.
You’d be amazed how many people are over-exfoliating, layering too many actives, or just not giving their skin what it really needs: a reliable moisture-and-lipid shield.
Crème VG Derm has been one of my go-tos for over a decade because it doesn't just mask dryness, it treats the root. It’s loaded with essential fatty acids that replenish what your skin is missing.
Think of it like a tailored coat for your face in winter, lightweight enough to move in, but structured enough to protect you from the elements.
Whether you're recovering from too much retinol, dealing with redness that won’t quit, or just feeling that uncomfortable “tight” feeling after cleansing, this is the fix. This cream helps restore balance, boost skin comfort, and make your skin feel like itself again.
You won’t just look better; you’ll feel better in your own skin.
Crème VG Derm: Your Go-To For Healing, Hydration, And Comfort

Crème VG Derm is one of those products I always have in my bathroom. It’s a rich, healing cream from Biologique Recherche that was designed for skin that needs to be soothed, comforted, and rebuilt. It's perfect for:
- Sensitive skin that flares up with the wrong cleanser
- Dehydrated skin that feels papery or tight
- Post-treatment skin that needs TLC
- Clients using actives like retinol, acids, or vitamin C
Why do I love Crème VG Derm?
Because it hydrates in intelligent layers. It starts with water-binding humectants that draw in moisture, then seals it all in with nourishing oils like jojoba and macadamia. But it’s not just about hydration, it physically reinforces your skin barrier.
Within a few days, you’ll notice your skin holding onto moisture better, feeling less reactive and more resilient. It also smooths out flaking, redness, and those uneven, angry patches with ingredients that actually feed the skin, not just coat it.
And the texture? Clients constantly tell me their skin feels soft, pillowy, and calm.
Can I Use Crème Vg Derm With Tretinoin?
Absolutely. In fact, if you're using retinol or any strong actives, Crème VG Derm is the partner you need. It soothes the dryness and helps prevent that raw, sensitized feeling.
Let your retinol do the work, but let Crème VG Derm do the healing.
Will This Clog Pores?
I’ve seen Crème VG Derm work beautifully even on acne-prone skin, as long as it’s in a dry or reactive state. If your skin is inflamed, your barrier is compromised, and that’s when this formula shines.
The oils are lightweight, and the cream is intelligently balanced, not suffocating.
Can I Use It With Acid Toners?
Yes, but timing is everything. I often recommend using your acid toner (like P50V for drier skin instants) in the morning and saving Crème VG Derm for nighttime repair. That way, your skin gets the benefit of both without being overwhelmed.
Breaking Down the Formula: Every Star Ingredient Explained

Clients always ask me what makes Crème VG Derm so special, and the answer is simple: it’s not one hero ingredient. It’s the way the entire formula works together to rebuild, restore, and rebalance your skin.
Let me break it down for you:
Macadamia & Cottonseed Oil
These are your lipid replenishment powerhouses. Macadamia mimics the skin’s natural sebum, while cottonseed is incredibly soothing and anti-inflammatory. Don’t worry, they’re non-comedogenic.
I’ve used Crème VG Derm on acne-prone clients during winter or post-treatment phases with zero issues.
Yeast Extract
This is where the real rejuvenation happens. Yeast extract helps support cellular turnover and boosts oxygenation, your skin starts to look more alive. It’s one of those ingredients you don’t feel instantly, but give it a week and the glow speaks for itself.
Jojoba Esters
If your skin barrier is a brick wall, jojoba esters are the mortar. They lock in hydration and stabilize the outer layer so you’re not losing moisture as fast. This is why Crème VG Derm is so good overnight, you wake up feeling hydrated, not tight.
Centella Asiatica
I always tell my clients this is the "rescue" ingredient. Whether you’re red, inflamed, or post-procedure, Centella accelerates healing and calms the drama. It’s part of Biologique Recherche’s exclusive botanical complex, and it works beautifully with yeast extract and Vitamin E.
Seabuckthorn (Omega-7)
This oil is like a skin vitamin. It delivers rare omega-7 fatty acids that support regeneration. Clients recovering from laser or chemical peels? I often layer this under Crème VG Derm for next-level soothing.
Niacinamide
Niacinamide does everything, evens tone, reduces redness, strengthens the barrier, and increases ceramide production. If your skin’s been screaming from overdoing it, this helps bring it back to baseline.
Vitamin E
This is your antioxidant bodyguard. It’s especially good for redness and reactivity. I find it also helps reduce visible damage from past inflammation.
Lactic Acid & Sodium Hyaluronate
This duo gently exfoliates and hydrates. Lactic acid smooths out rough patches while sodium hyaluronate draws in moisture at a deeper level.
This combo is what makes Crème VG Derm feel like your skin is drinking a tall glass of water, with benefits.
What Not To Mix With Crème VG Derm

Crème VG Derm plays beautifully in most routines, but I always remind clients: just because it’s gentle doesn’t mean it should be layered with everything. Some combinations can overwhelm your skin or cancel out the cream’s calming benefits.
Strong Vitamin C (L-Ascorbic Acid)
I love a good vitamin C, but the pure form (L-Ascorbic Acid) can be aggressive, especially when your skin barrier is already compromised.
Pairing it with Crème VG Derm can increase sensitivity or redness, especially if you’re already using retinoids or exfoliants.
High-dose AHAs/BHAs
Crème VG Derm already contains lactic acid, which gently resurfaces while hydrating. Adding more exfoliating acids (like glycolic or salicylic) on top can be too much, leading to over-processing, flaking, or breakouts.
Essential Oil-Heavy Products
Many essential oil-rich formulas don’t belong in a compromised skin routine. They can irritate and even undo the calming effects of Crème VG Derm. Stick to fragrance-free or low-fragrance products while your skin is healing.
Best Biologique Recherche Products To Pair With Crème VG Derm
If you want to build a high-performance routine around Crème VG Derm, these are the products I always recommend in-clinic and personally use at home.
They prep, support, and amplify what Crème VG Derm does best, repair and hydrate.
Lait E.V. Cleanser

This is your creamy, cushiony first step. It gently lifts makeup and impurities without stripping your skin, so important when your barrier is fragile. It sets the tone for everything that follows.
Lotion P50V

This version of Biologique Recherche’s cult exfoliating toner is ideal for mature or devitalized skin. It gently exfoliates while delivering nourishing ingredients that support elasticity.
Used before Crème VG Derm, it helps clear the way for deeper penetration and better hydration. I’ve seen it completely revive tired, uneven texture when used consistently and mindfully.
Serum Amniotique VG

This is a hydrating serum that works beautifully under Crème VG Derm, especially in warmer seasons or humid climates. It’s lighter than Serum Colostrum VG but still delivers intense moisture, making it ideal for layering when you don’t want to feel too heavy.
Colostrum VG Serum

When a client tells me their skin feels “angry” or “thin,” I go straight to Colostrum VG. It deeply hydrates and helps regenerate the skin. Layer it under Crème VG Derm for a cocooning, healing effect, especially in the winter or after a procedure.
Masque Visolastine +

This mask is a hydration reset for dry, depleted skin. I often recommend using it once a week before applying Crème VG Derm; it deeply moisturizes, softens tightness, and restores comfort.
The skin feels plump, calm, and perfectly primed to soak in every drop of your moisturizer.
From Rosacea to Recovery: The Cream That Changes Skin
Crème VG Derm isn’t just another moisturizer on the shelf, it’s one of the most-used products in our studio, and in my own skincare routine. I’ve applied it on hundreds of faces over the years, and here’s where it truly shines:
- Rosacea and inflammation , It calms the storm without clogging pores or overloading sensitive skin.
- Post-laser or microneedling healing , It supports regeneration beautifully and helps prevent that dry, tight rebound effect.
- Winter skin and extreme dehydration , When central heating, cold air, or airplane travel wreck your skin, this cream brings it back to life.
Clients don’t just see results, they feel them. Softer texture, less redness, more resilience. It’s like your skin remembers how to function again.
Barrier First, Beauty Always

If you’re reading this, chances are your skin has been through it. Maybe it’s red, reactive, or just chronically dry no matter what you use. Maybe your barrier has been slowly breaking down from actives, stress, or environmental exposure.
You’re not alone, and you don’t need another trendy product. You need real skin recovery. Crème VG Derm is your reset button.
Whether you’re new to Biologique Recherche or already love the brand, this cream anchors your routine with comfort, strength, and real results. KarinaNYC is here to make sure it’s not just about what you use, but how you use it.
Here’s How We Can Help:
👩🔬 Free Skin Consultation
Our team will assess your skin type, history, and goals to recommend the perfect combination of BR products, because one size never fits all.
🛒 Shop Crème VG Derm at KarinaNYC
We only carry authentic, tested formulas. I use every product we sell, and I stand behind them fully.
🧴 Try the Barrier Reset Protocol
A curated trio of Crème VG Derm, Colostrum VG, and P50W, designed to soothe, strengthen, and restore stressed skin. Ideal for anyone healing from over-exfoliation, winter stress, or just needing to start fresh.
You deserve skin that feels calm, resilient, and radiant, not just for today, but long-term. KarinaNYC believes in skincare that actually works, and Crème VG Derm is proof.
Let’s rebuild your skin barrier, together.