Amniotique VG hydrates dehydrated skin with lightweight moisture, while Colostrum VG soothes and nourishes very dry or barrier-damaged skin. Choose Amniotique for water-based hydration and Colostrum for deeper comfort. Read on for a side-by-side comparison, uses, and expert insights.
Biologique Recherche’s serum line is vast, and if you’re choosing between Amniotique VG and Colostrum VG, you’re already deep in expert territory. But even experienced skincare lovers can get confused. Karina NYC’s expert consultations often uncover one thing: most people are using the wrong serum, or using it wrong.
In this guide, we’ll break down what each of these cult-favorite serums does, who they’re for, and how to use them right. Let’s get you the skin-changing results you paid for.
The Serum Confusion Ends Here
Biologique Recherche doesn’t play around. Their serums are unlike anything else on the market, ultra-concentrated, highly specific, and designed for real results.
But that also means they can be... overwhelming.
I’ve seen firsthand how easy it is for even savvy skincare lovers to mix up serums like Amniotique VG and Colostrum VG.
Both are labeled “hydrating.” But trust me, if you choose the wrong one, your skin will tell you.
So let’s clear it up, once and for all: What’s the difference between these two cult-favorite serums? Who are they for? And how do you know which one your skin really needs?
Dehydrated Or Dry? Here's The Right Serum For You
Feeling tight, flaky, or just “off”? Not all dryness is created equal, and choosing the wrong serum can make it worse.
Here’s how to tell if your skin is dehydrated or dry, and exactly which Biologique Recherche serum (Amniotique or Colostrum) will actually help.
Serum Amniotique VG: For Dehydrated, Tight, Stressed Skin
This is one of my go-to serums when a client sits in my chair and says, “My skin just feels tight all the time.” You know that paper-thin, dry-but-oily feeling? That’s classic dehydration, not dryness, and Amniotique VG is magic for it.
You’ll love this serum if you:
- Feel tightness or discomfort after cleansing
- Notice your skin drinks up moisturizers too quickly
- Live in a humid climate but still feel dry
- Travel a lot, especially by air
- Want hydration without heaviness (hello, makeup prep!)
What It Does
Amniotique VG delivers long-lasting, water-based hydration using botanical humectants like algae and prickly pear. It mimics your skin’s natural hydration mechanism, restoring bounce and elasticity without clogging pores.
And because it’s non-comedogenic, even my acne-prone clients can use it safely.
Key Ingredients
- Opuntia Ficus-Indica Extract – boosts moisture retention
- Algae & Papaver Petal Extract – soothe and balance
- Panthenol & Glycerin – draw and lock in water
- Lactic Acid – gently smooths for better absorption
When It Shines
I always pack this for travel, it’s like giving your skin a tall glass of water after a long flight. I also recommend it during warmer months when you want to keep your skin hydrated without feeling greasy. Clients also love it under sheet masks and makeup for that healthy, natural glow.
Just don’t let its light texture fool you, used right, Amniotique VG hydrates deeply.
The key is pressing it in, not rubbing. A few drops go a long way.
Colostrum VG: For Dry, Damaged, Barrier-Compromised Skin
Now this one, Colostrum VG, has a whole different vibe. I call it “comfort in a bottle.” It’s what I reach for when a client’s skin is fragile, red, flaky, or just... angry.
Whether it’s post-procedure recovery, over-exfoliation, or a brutal winter, this serum steps in like a warm, healing hug.
Reach for Colostrum VG if you:
- Have very dry, irritated, or flaking skin
- Are recovering from microneedling, peels, or lasers
- Struggle with eczema, rosacea, or barrier damage
- Feel your skin just won’t “hold” moisture anymore
- Need serious protection during cold weather
What It Does
Unlike Amniotique, which hydrates by drawing in water, Colostrum VG works by soothing and rebuilding your skin’s lipid layer. It’s not an oil (common mistake!), but it does provide lipid-like comfort.
That’s why it’s so brilliant for skin that feels raw or sensitive, it supports repair, not just hydration.
Key Ingredients
- Biological Colostrum – milk proteins that mimic healing factors
- Saccharide Isomerate – long-lasting hydration that binds to skin
- Caprylic/Capric Triglyceride – emollient and replenishing
- Tocopherol (Vitamin E) – antioxidant and barrier support
When It Shines
This serum is gold in colder months, after any intense skin treatment, or when your skin barrier has waved the white flag. I often blend it into cream masks like Creme Masque Vernix for my post-travel or hormonal skin clients.
And if you’re navigating menopause or postpartum sensitivity, Colostrum VG can be a game-changer.
Pro tip: Always apply it on damp skin, right after cleansing or misting. It helps with absorption and prevents that slightly tacky feeling it can leave behind if applied too dry.
Amniotique VG Vs Colostrum VG: Which One Does Your Skin Need?
If your skin feels tight but not flaky, you’re likely dehydrated: Amniotique VG is your girl.
Its lightweight, water-based texture sinks in instantly and gives stressed, thirsty skin a much-needed drink. It's best for spring and summer, or humid climates where you want hydration without any weight. Just apply 2–3 drops after P50 and before your cream.
But note: it’s not ideal for mature or lipid-depleted skin, you’ll need something more reparative.
Now, if your skin is visibly dry, flaky, or recovering from stress (like post-peel, post-travel, or hormonal changes), Colostrum VG is your rescue serum. It’s a touch denser and rich with comforting ingredients that soothe and rebuild the skin’s lipid barrier.
Apply it on slightly damp skin for best results. It shines in colder months, but if you’re oily or breakout-prone, it may be too much.
Different seasons, different skin states, different serums. The key is knowing what your skin needs today, not what it needed last month.
I Used Both And My Skin Got Worse.
I see it all the time: people layer both serums, thinking more = better. But in this case, more often means irritation, clogged pores, or feeling like nothing’s working.
Biologique Recherche products are potent. You don’t need to cocktail them unless you really know what you’re doing (or are working with a BR-trained facialist).
Stick with one hydrating serum that fits your current needs, and always follow with the right moisturizer and, ideally, a finishing serum to lock it in. Your skin will feel more balanced, not overloaded.
Don’t Waste Your Serum, Apply It Like This
Even the best serum won’t work if it’s layered wrong. BR is a system, not a standalone product. The way you prep your skin before applying Amniotique VG or Colostrum VG can make or break your results.
Here’s how I recommend using these serums, for yourself or in my treatment room:
Step 1: Start With The Right Cleanser
Choose a Lait cleanser that matches your skin’s instant, not just your type.
Massage it in slowly with damp fingers, rinse with cool water (never hot!), and gently pat dry with a clean towel.
Step 2: Exfoliate Gently With Lotion P50
This step preps your skin like no other, but only if you’re using the right P50 variant.
Soak a cotton round and press, don’t sweep. Let it dry fully before layering your serum.
Step 3: Apply Your BR Serum (The Right Way)
Whether you’re using Amniotique VG or Colostrum VG, keep it simple:
- Use 2–3 drops max, BR formulas are potent.
- Press into the skin, don’t rub or drag.
- If using Colostrum, apply it on slightly damp skin to enhance absorption and reduce that sticky finish some people notice.
Let the serum sink in for about a minute before moving on.
Step 4: Follow With A Targeted Moisturizer
Choose your cream based on what your skin needs right now:
- For oil imbalance or dehydration, go with Crème Dermopurifiante, it’s balancing and helps calm inflammation.
- If your barrier is compromised, or your skin feels raw or sensitive, I swear by Crème Masque Vernix. It’s healing, breathable, and feels like second skin.
Step 5 (Optional): Lock It In With A Finishing Layer
If your skin needs extra protection, especially in dry indoor air or cold climates, add a final lipidic shield:
- Serum TEWL or Grand Millésime can seal in all the layers underneath and help prevent trans-epidermal water loss. Think of it as your skin’s overcoat.
Perfect Pairings: Top BR Products To Use With Each Serum
BR isn’t a plug-and-play brand, it’s a system. And when you pair your serums with the right supporting products, that’s when the magic really happens.
The KarinaNYC Difference: Your Skin Needs More Than A Serum
You’re not just buying skincare, you’re investing in your skin.=
And with Biologique Recherche, every product matters. But even the most luxurious serum can work against you if it’s not used with intention, or if it doesn’t match your skin’s real needs.
That’s where I come in.
For over two decades, I’ve been helping women (and men) cut through the confusion and get results that last. And I’ll be honest with you, my skin looks better now than it did 25 years ago. That’s strategy, consistency, and using the right products at the right time.
If your skin feels like it’s plateaued, or worse, reacting, it’s not about buying more. It’s about understanding what your skin is asking for… and answering it with the right tools.
Karina’s Solutions For Skin That Actually Glows
✨ Free Expert Consultation
→ Not sure if you need Amniotique VG, Colostrum VG, or something else entirely? Let’s find out together. Book a no-pressure skin consult online with our team, it’s fast, judgment-free, and always honest.
🧴 Pre-Vetted Product Selection
→ Every single product on our shelves has been tested by me. We don’t stock fluff. If it’s in our clinic, it works. No hype, just hard-won results.
💆♀️ Signature Biologique Recherche Facials
→ There’s no substitute for touch. In our NYC studio, your skin is assessed, understood, and treated with clinical-grade BR protocols. You’ll walk out glowing, and with a routine that finally makes sense.
Your skin isn’t just a canvas. It’s a living, breathing system that deserves respect, not guesswork. Let’s treat it that way, together.
Whenever you're ready, we’re here.
