Apply a hazelnut-sized amount of Crème ISO-Placenta to clean skin after P50 and serums, morning or night. It targets post-acne scars, redness, and texture.
Use consistently to restore your barrier and fade discoloration. It’s best for skin healing from breakouts, irritation, or aesthetic treatments.
At KarinaNYC, we guide clients through results-driven routines so every product pulls its weight.
If you’ve ever been burned by skincare that didn’t deliver, this one’s for you. Read on to learn exactly how, and when, to use it.
Not Just Another Moisturizer: Why Crème ISO-Placenta Deserves a Spot in Your Routine
Crème ISO-Placenta isn’t your average moisturizer. It’s a high-performance recovery cream designed to mimic the regenerative effects of human placenta peptides, without any animal-derived ingredients.
That means powerful healing, vegan-safe, and deeply restorative care for your skin’s most vulnerable moments.
If your skin is recovering from breakouts, peels, microneedling, or simply feels raw and reactive, this is your ally. It was made to target post-acne scarring, redness, and that frustrating texture that never quite smooths out on its own.
I use it on clients who’ve just come off months of inflammation, clients who thought their skin would never bounce back. And guess what? It does.
The formula is fragrance-free, non-comedogenic, and cold-formulated, which means none of the active ingredients were damaged by heat. This matters more than most people realize.
So many creams lose potency before they even hit your shelf. We don’t play that game.
Don’t Just Slather It On, Here’s How to Actually Use ISO-Placenta
If you’ve been layering your products in the wrong order, don’t worry, most people are. But when it comes to a treatment cream like Crème ISO-Placenta, application order makes all the difference.
This isn’t just a moisturizer; it’s a repair tool. And tools only work when used properly.
From Cleansing to Sealing: A Routine That Makes ISO-Placenta Work Smarter
When you’re healing your skin, it’s not just about the product, it’s about the routine.
Think of Crème ISO-Placenta as one of the lead actors in your skincare script, but the supporting cast matters just as much.
Here’s how I guide my clients to structure their routine so every product works in harmony.
1. Cleanse
Start with a gentle milk cleanser:
Lait Dermo-S is my go-to for most skin types
Lait EV if your skin feels dry or tired
Lait S.R. if you’re dealing with excess oil or congestion
2. Exfoliate
Follow with Lotion P50 to exfoliate and rebalance.
If your skin is sensitive, opt for P50W
This step is non-negotiable. Think of P50 as your skincare primer, it allows the actives in ISO-Placenta to absorb and perform properly.
3. Hydrate With A Quintessential Serum
Choose one based on your skin’s needs:
Extraits Tissulaires for oily or dehydrated skin
Amniotique VG for lightweight hydration
Colostrum VG if your barrier is compromised or your skin feels raw
4. Treat With Crème ISO-Placenta
Now apply your Crème ISO-Placenta. This is the healing step.
Gently press it into your skin and let it absorb without rubbing or overworking it.
4. Seal
Finish with a few drops of Serum Silk Plus, my favorite for smoothing texture, adding hydration, and giving that velvety finish without heaviness.
It creates a breathable, protective veil over the skin, sealing in all the actives underneath while leaving your complexion soft, calm, and subtly radiant.
How Much To Use
A hazelnut-sized amount is perfect for your entire face, neck, and décolleté. More is not better here.
You want a sheer layer, just enough to work its magic without overwhelming your skin.
Morning & Night?
Yes, you can use it twice a day. I do, especially during recovery phases.
But if your skin leans oily, you might prefer using it in the morning only, when its calming, non-greasy texture can double as a soothing base under SPF.
At night, consider switching to Crème Dermopurifiante if breakouts are still flaring.
Application Mistakes To Avoid
Let’s talk mistakes, because they’re easy to make:
Broken skin or open breakouts? Skip this cream. It’s designed for healing, not fighting. Use it once the inflammation has cooled.
On tretinoin or acids? Don’t layer ISO-Placenta directly on top. Alternate nights, or buffer with Masque Vernix to avoid overstimulation.
Skipping P50? Big no. Without that gentle exfoliation, your skin is less able to absorb what this cream offers.
Use ISO-Placenta like you’d use a post-surgical wrap: not aggressively, but with care, purpose, and consistency. And that’s when the healing begins.
Frequency by Skin Type
Oily/Combination Skin: Once a day, ideally in the morning under SPF. The lightweight, non-oily texture won’t cause congestion.
Reactive or Recovery Skin: Twice daily. This is when ISO-Placenta really shines, morning and night will keep inflammation down and healing on track.
Post-Treatment Skin: Use only at night to allow skin to rest and rebuild without interference from daytime environmental stress.
Timeline of Results
Let’s manage expectations realistically, because real healing doesn’t happen overnight. But with consistency and the right support, the shift is undeniable.
Week 1–2: You’ll start noticing small but important changes. Redness begins to fade, skin feels calmer, and hydration rebounds, especially if you’ve been feeling tight or flaky. This is your barrier stabilizing. It’s a quiet kind of progress, but it’s foundational.
Week 3–4: Pigmented marks from past breakouts begin to lighten. Your overall tone starts looking more even and less blotchy. You might notice makeup going on smoother, or that you need less of it.
Week 5–6: Texture begins to visibly improve. Bumps smooth out, rough patches soften, and those lingering scars start to flatten. The skin feels more uniform under your fingertips.
Week 7–8: Radiance returns. Your complexion looks more balanced, more resilient, and better able to “bounce back” from stress.
Clients who stick to this routine often see visible transformation by the second month, but the key is consistency. Healing doesn’t happen overnight, but with ISO-Placenta, it absolutely happens.
Bonus Tips
Store in a cool spot, like your skincare fridge or a cabinet away from sunlight, to preserve the potency of actives.
Avoid the eye area, this formula is too active for the delicate tissue around your eyes.
Using retinoids? Layer Masque Vernix afterward to buffer the intensity and help rebuild your lipid barrier. This duo is one of my favorites for clients on prescription skincare who want to avoid peeling or dryness.
Frustrated With Your Progress? Let’s Troubleshoot Together
Skincare can be confusing, especially when you're investing in high-performance products like Crème ISO-Placenta.
I hear the same concerns from clients all the time, and I get it. If your skin is already stressed, the last thing you want is more trial and error.
Here’s what you need to know:
Will This Clog My Pores?
No, ISO-Placenta is non-comedogenic. It hydrates without suffocating your skin, which is why I trust it even for oily and acne-prone clients.
That said, if you’re using five different serums plus a heavy sunscreen and makeup, congestion can happen, less is more. Let this cream shine by keeping your routine streamlined.
Can I Use It With Tretinoin?
Yes, but carefully. I usually recommend alternating nights.
Tretinoin is powerful, and while ISO-Placenta helps calm and rebuild, layering them can be too much at once.
If your skin is flaking or sensitized, apply ISO-Placenta the night after tretinoin, and buffer it with Masque Vernix when needed. That combo has saved so many of my clients' faces in winter.
My Skin Feels Worse After A Week, Is That Purging?
Probably not. ISO-Placenta isn’t an exfoliating product, so it’s not meant to trigger purging.
If your skin feels irritated or red, it could be barrier disruption from something else in your routine. That’s when we step in. Book a consult, we’ll take the guesswork out and find the true cause.
What If I’m Still Breaking Out?
Then it’s not time for ISO-Placenta yet. Healing comes after calming.
If you’re still experiencing active, inflamed breakouts, I reach for Crème Dermopurifiante or Serum Iribiol first.
Once we reduce the inflammation, then we switch to ISO-Placenta to prevent scars and rebuild the skin. It’s all about the right product at the right phase.
Heal Smarter With KarinaNYC
When your skin is raw, inflamed, or marked by past breakouts, the last thing you need is more skincare confusion.
Crème ISO-Placenta isn’t a miracle in a jar, it’s a clinically formulated recovery cream that only delivers when you know how to use it.
I’ve spent years helping clients get real results from this formula, and the truth is, success comes from precision, not guesswork.
What Healing Looks Like With The Right Guidance
🌿 Product Matchmaking Consultation
Stop guessing. We assess your skin’s real-time condition and build a routine that meets it exactly where it is. That includes when (and when not) to use ISO-Placenta.
🧴 Authentic BR Products, Stored Properly
Every product we carry is cold-stored, fresh, and verified, because we know heat-damaged actives don’t heal anything.
🧖🏽♀️ Clinic-Level Facials for Accelerated Healing
Our facials aren’t fluff, they’re targeted treatments using BR protocols to calm, resurface, and restore your skin faster than at-home care alone.
You don’t have to navigate your healing journey solo. We’re here when you're ready to turn trial-and-error into transformation.
