Apply 1ml of Serum Oligo-Protéines Marines on clean skin after Lotion P50, using gentle upward strokes. Use daily for 3–4 weeks, then pause for one. It’s best for dull, tired, or dark-circle-prone skin but like all Biologique Recherche products, it only works if used the right way.
At KarinaNYC, we teach our clients to get the most from every drop.
Let’s break it down step-by-step so your serum works smarter, not harder.
Skincare That Works: Karina’s Protocol For Oligo-Protéines Marines
If you’ve ever looked in the mirror after a red-eye flight, a week of poor sleep, or a stressful stretch at work and thought, my skin looks exhausted, then Serum Oligo-Protéines Marines was made for you.
At KarinaNYC, we call it our “urban skin reset” because it recharges skin that’s dull, oxygen-starved, or just flat-out tired.
It’s especially powerful for city dwellers, smokers, new moms, and night owls, anyone whose lifestyle shows up on their face. The lightweight, water-based formula sinks in fast and never clogs.
Key ingredients like marine oligopeptides, spirulina, caffeine, niacinamide, and malachite extract work together to brighten, energize, de-puff, and protect.
But if you’re allergic to iodine or seafood, skip this one.
It’s potent because it’s marine-derived, loaded with sea-sourced minerals that boost cellular renewal. That’s what gives it its signature effect: skin that looks like it just came back from vacation, even if you haven’t left your desk.
Wake Up Your Skin: A Step-By-Step Guide To Serum Oligo-Protéines Marines
(instagram video: https://www.instagram.com/p/BxPgg-8HDGE/)
If you’re using Oligo-Protéines Marines, you want results, fast.
But like anything in skincare, results come from precision and consistency. This serum is potent, so treat it with intention.
Step 1: Prep Like A Pro.
Start with a gentle cleanse using Lait E.V. if your skin leans sensitive or feels devitalized. It nourishes while cleansing and sets the tone for what’s to come.
Follow with Lotion P50: my non-negotiable. It preps your skin for better absorption and clears the “static” that blocks actives from working.
Step 2: Measure Your Dose.
You don’t need to overdo it. 1ml, around 20 drops, is enough for your face, neck, and décolleté.
At KarinaNYC, I often customize dosage by face shape. Petite faces? You might only need 6–8 drops.
Step 3: The Method Matters.
Apply using upward strokes, never downward dragging.
Always move from center outwards and bottom to top. This isn’t lotion, this is therapy. Massage it in lightly, and give it a moment to sink in.
Step 4: Timing Is Everything.
Let it absorb completely before layering your moisturizer. Never rush this part. I usually recommend waiting about 30–60 seconds before the next step.
Step 5: Build A Rhythm.
Use it 5 to 7 times per week for a full month. Then stop. Yes, stop. This serum works best in cycles. Give your skin a 7–10 day break before restarting.
Think of it as a high-intensity workout for your skin, you need rest days, too.
Sensitive Skin Tip:
If you’re reactive or new to BR, begin with 2–3 applications per week. Or even dilute 1 drop into your moisturizer at night.
My sensitive clients see amazing results when they ease into it instead of diving headfirst.
How It Differs From Other BR Serums
Not all BR serums do the same thing. And believe me, I’ve tested them all.
Versus Placenta:
Placenta is your go-to for healing, especially post-acne or post-procedure. It fades red marks, rebuilds texture. Oligo, on the other hand, wakes the skin up immediately. Think brightness, energy, and “I slept eight hours” skin.Versus Colostrum:
Colostrum is rich, milky, nurturing, like a hug for dry, fragile skin. I love it in the winter. Oligo is your espresso shot. It's energizing, lightweight, and designed to stimulate, not calm.Versus Extraits Tissulaires:
Tissulaires is ideal for oily, dehydrated skin. It hydrates without adding weight. Oligo is for dullness. It tackles gray tone, fatigue, and lack of oxygen. Totally different jobs, both brilliant in the right routine.
Choosing the right serum is half the battle.
If you're unsure where to start, that's what we do best at KarinaNYC, customize every detail. Because no one should be wasting beautiful product with the wrong protocol.
Building The Perfect Routine With Serum Oligo-Protéines Marines
This serum isn’t a solo artist, it performs best in an ensemble.
At KarinaNYC, I don’t just hand clients a product and send them off. We build a symphony of actives tailored to what their skin actually needs, and when.
Let’s walk through how to slot Oligo-Protéines Marines into your skincare routine for maximum effect.
Layering Order (AM)
Here’s your glow protocol for mornings when your skin needs energy, brightness, and resilience:
1. Cleanser
Use Lait E.V. for dry, devitalized skin that needs nourishment, or Lait Dermo-S if your skin is sensitive, irritated, or recovering from stress. Both offer a gentle cleanse without stripping your barrier.
2. Lotion P50
The gold standard for exfoliation and balance. Use Lotion P50V for normal to dry skin, or P50W if you’re sensitive or new to BR. This preps the skin and clears away dead cells that can block serums from penetrating.
If you want uneven skin tone or pigmentation is your skin concern, P50 PIGM 400 makes a great combo with Oligo-Proteines.
3. Serum Oligo-Protéines Marines
Apply 1ml and press into face, neck, and décolleté. This is your skin’s caffeine shot, it energizes, brightens, and revives tired skin.
4. Finishing Serum
Choose Serum Grand Millésime if you want anti-aging radiance, or Serum Yall-O2 for plumping hydration and environmental defense. If you have combination skin, use Silk Plus for a lightweight finish.
5. Sunscreen
This step is non-negotiable. After oxygenating and stimulating your skin, you must shield it. Choose a broad-spectrum SPF 30 or higher that plays well with serums.
💡 Pro Tip: If you wear makeup, wait at least 5 minutes after applying Oligo to allow it to fully absorb. It’s light, but rushing may cause pilling or interfere with smooth makeup application.
Layering Order (PM)
Evenings are when skin goes into repair mode, and Oligo-Protéines Marines steps in to recharge:
1. Cleanser
Use Lait E.V. if your skin feels depleted, or Lait Dermo-S if you're recovering from flare-ups, procedures, or environmental stress. If you have congested skin, you can also use Lait S.R.
2. Lotion P50
Lotion P50W is optional for compromised or sensitive skin. If your barrier feels inflamed or fragile, skip it that night and focus on calm.
3. Serum Oligo-Protéines Marines
This is your nighttime reset. Press it in gently and let it sink into clean, toned skin.
4. Cream
Seal it in with Creme Biofixine for anti-aging and wrinkle-smoothing benefits, or Creme MSR-H if your skin is mature, dry, or hormonally imbalanced. For reactive skin, Creme Dermopurifiante helps purify without stripping. If you’re trying to even out your complexion, use Creme Iso-Placenta.
This routine is designed not just for luxury, it’s for results. Every product serves a role, every layer a purpose. With the right sequence, even a tired, overworked complexion can find its rhythm again.
Custom Frequency By Skin Type
Normal/Dull Skin: Use Oligo daily for a full month, then take a 7–10 day break.
Sensitive Skin: Start with 2–3 times per week. Build tolerance gradually to avoid flare-ups.
Post-Procedure: If you’ve had microneedling, laser, or deep exfoliation, wait 48–72 hours before introducing Oligo. Your skin needs time to settle first.
Can I Use This Right After A Facial?
Only if your facial didn’t include heavy exfoliation or retinol. Otherwise, give it 1–2 days.
When to Use It (Timing)
AM: Use in the morning when you want to look rested, lifted, and lit from within.
PM: Use in the evening for deep skin recovery, especially after stress, late nights, or travel.
Can I Wear Makeup Over It?”
Absolutely. But only after it’s fully absorbed. I’ve seen it work beautifully under tinted SPF and even heavier foundation, as long as you give it a few minutes to settle.
Rushing this step can cause pilling, and you’ll lose all that gorgeous radiance you just paid for.
When used at the right time, in the right routine, Oligo-Protéines Marines isn’t just a serum. It’s your skin’s comeback plan.
How Fast Does It Work? Your Oligo Results, Week By Week
Skincare is not magic, it’s chemistry, and chemistry takes time. But when you use Serum Oligo-Protéines Marines correctly and consistently, the transformation is real.
Here's what most of my clients (and I) experience over a typical month of use:
Week 1: The Subtle Shift
By the end of the first week, your skin starts to take on a soft, diffused glow, like you’ve just come back from a weekend at the spa. Texture begins to smooth out, and tone looks more even.
It’s subtle, but unmistakable. I call this the “mirror double take” phase.
Week 2: Eyes Begin To Brighten
Clients often report lightening of dark circles and under-eye puffiness, especially if they've stored the serum in the fridge, as I recommend.
Caffeine and marine extracts decongest those tired areas. If you’ve ever had that sunken, exhausted look under the eyes, this is where you’ll start seeing the lift.
Week 3: That Well-Rested Look
By now, people start asking if you’ve been sleeping better. Even if you haven’t.
The complexion looks more even, more rested, like your skin finally caught up on sleep.
Week 4: Stronger, Smoother, Resilient Skin
At the end of the month, you’ll notice better elasticity, smoother surface texture, and a visible reduction in stress-induced dullness.
Skin feels more stable, less reactive, less “tired.” That’s the power of consistent microcirculation and oxygenation.
Why Does My Skin Purge When I Start It?
This serum stimulates microcirculation and detoxification. If your skin has been stagnant or congested, it may purge a little at first. That’s okay, and actually a sign it’s working.
Just slow your usage to 2x/week and ease into daily use.
Do I Need A Break After One Month?
Yes. Always. At KarinaNYC, I teach clients to think in cycles. Oligo is potent, and your skin responds best when given time to reset.
After 4 weeks of use, take a 7–10 day break before starting again. This pause helps your results consolidate, and prevents plateauing.
Consistency is key, but wisdom is what makes it work. Give it time, and your skin will return the favor.
Avoid These Pitfalls If You Want Real Results
Even the best product won’t deliver if it’s used the wrong way. Oligo-Protéines Marines is powerful, but precision matters.
Here are the missteps I see far too often, and how to sidestep them:
❌ Using too much product
Twenty drops is plenty for your entire face, neck, and décolleté. More doesn’t equal better. In fact, overuse can overwhelm the skin and waste the serum.
❌ Mixing with acids, retinol, or harsh exfoliants
Oligo is stimulating on its own. Layering it with aggressive actives like glycolic or tretinoin can trigger irritation or purging. Keep your routine balanced.
❌ Using too often on reactive skin
If your skin is sensitive or recovering, ease in slowly. Start 2–3x/week and work up. I’ve had clients purge unnecessarily simply because they jumped in too fast.
❌ Skipping a break after 4 weeks
This is one of the parts that matter. Oligo works in cycles. Use for 4 weeks, then rest. Overuse flattens its impact over time.
❌ Using during active dermatitis or rosacea flare-ups
Oligo is energizing, not calming. If your skin is inflamed, red, or flaring, wait. Treat the inflammation first, then reintroduce this serum when your barrier is stable.
The bottom line? This serum isn’t a casual step. It’s a commitment to brighter, stronger, more resilient skin. Treat it like the tool it is, and it’ll deliver every time.
Real Skin, Real Results: The KarinaNYC Way
If you’ve been using Biologique Recherche and feel underwhelmed by the results, it’s probably not the serum, it’s the strategy.
I’ve seen it over and over. Women (and men) invest hundreds on incredible products, but apply them in the wrong order, at the wrong frequency, or mix things that were never meant to be layered.
That’s how you end up with a $150 serum sitting in your bathroom collecting dust.
Oligo-Protéines Marines, in particular, is a precision tool, not a catch-all solution. It shines when used with clarity and care.
This isn’t for everyone. It’s for the skincare lovers who want real results.
The jet-lagged executives, the exhausted moms, the urban warriors with tech-stressed skin. If you’ve outgrown gimmicks and want a routine that actually works with your lifestyle and your biology, you’re in the right place.
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You’ve invested in your skin. Now it’s time to make that investment work harder. Let KarinaNYC be your guide, because beautiful skin isn’t luck. It’s a strategy.
